Perampanel overdose in low body mass index patients with epilepsy: a case report and review of the literature

Table 1 Characteristics of perampanel overdose patients from different case reports

Case report	Age (years)	Previous diagnosis	Weight	Dose of perampanel	Co-medications	Vital signs	Initial neurological manifestation	Systemic manifestation	Duration to recovery	Specific treatment	Full recovery
Hoppner et al.	35	Refractory epilepsy	NA	204 mg (25.5 times her daily dose)	Levetiracetam Topiramate Pregabalin	NA	Dysarthria followed by stupor	No	2 days	No^a	Yes^b
Li et al.	54	Refractory epilepsy	NA	300 mg	Divalproex sodium Lamotrigine Levetiracetam	Heart rate 58/minute Other findings were unremarkable	Marked somnolence Disconjugate gaze with 3 mm reactive pupils bilaterally	Serum sodium 128 mEq/L	4 days	No^c	Lost to follow-up
Kim et al.	39	Epilepsy	NA	40 mg (10 times her daily dose)	Valproic acid	Normal	Stupor	Normal^d	8 days^e	No^c	Yes^b
Wu et al.	40	Depression and anxiety disorders, polysubstance abuse	NA	60 mg^f	NA	Respiratory rate 6/minute^g	Unresponsive then extremely agitated next day	Normal	5 days	No^c	NA
Our report		Refractory epilepsy		80 mg (40 times her daily dose)	Lamotrigine	Normal	Drowsiness	Normal	3 days	No^a	Yes^b

NA not available
^aInvolved gastric lavage
^bFull recovery to baseline before perampanel overdose
^cNo report of gastric lavage
^dPulmonary embolism on day 3
^eDuration to recovery comprised the time required for recovery from both perampanel overdose and pulmonary embolism
^fFirst time of perampanel ingestion
^gUrine screening positive for benzodiazepine and ethanol

ISSN: 1752-1947