Case report | Age (years) | Previous diagnosis | Weight | Dose of perampanel | Co-medications | Vital signs | Initial neurological manifestation | Systemic manifestation | Duration to recovery | Specific treatment | Full recovery |
---|---|---|---|---|---|---|---|---|---|---|---|
Hoppner et al. | 35 | Refractory epilepsy | NA | 204 mg (25.5 times her daily dose) | Levetiracetam Topiramate Pregabalin | NA | Dysarthria followed by stupor | No | 2 days | Noa | Yesb |
Li et al. | 54 | Refractory epilepsy | NA | 300 mg | Divalproex sodium Lamotrigine Levetiracetam | Heart rate 58/minute Other findings were unremarkable | Marked somnolence Disconjugate gaze with 3 mm reactive pupils bilaterally | Serum sodium 128 mEq/L | 4 days | Noc | Lost to follow-up |
Kim et al. | 39 | Epilepsy | NA | 40 mg (10 times her daily dose) | Valproic acid | Normal | Stupor | Normald | 8 dayse | Noc | Yesb |
Wu et al. | 40 | Depression and anxiety disorders, polysubstance abuse | NA | 60 mgf | NA | Respiratory rate 6/minuteg | Unresponsive then extremely agitated next day | Normal | 5 days | Noc | NA |
Our report | Refractory epilepsy | 80 mg (40 times her daily dose) | Lamotrigine | Normal | Drowsiness | Normal | 3 days | Noa | Yesb |