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Table 2 Summary of clinical and laboratory investigations done

From: Clinical presentation of congenital syphilis in a rotavirus vaccine cohort study in Lusaka: a case series

Characteristic Case 1 Case 2 Case 3 Case 4 Case 5 Case 6 Case 7 Mean (SD)
Age at presentation (days) 4 5 42 120 28 105 60 Median (IQR)
42 (5–105)
Age at diagnosis (months) 5 5.5 6 5 4 4 2 4.5 (1.3)
Presenting symptoms Conjunctivitis RTI Coryza RTI Dermatitis Coryza Coryza  
Birth weight (kg) 3.2 2.2 3.5 3.7 3.4 3.6 2.9 3.2 (0.5)
Mother screened at antenatal care No No No Yes (NR) No No No  
HIV status CNE CE CNE CNE CE CNE CE  
Weight at diagnosis (kg) 5.4 6.3 6.4 6.8 4.6 5.6 3.8 5.6 (1.1)
Length at diagnosis (cm) 64 63 64 67 58.5 64 53 61.9 (4.7)
Z-score at diagnosis
 Weight for length z score (WHZ) (wasting < −2 SD) −3 < −2 −2 < −1 −2 < −1 −2 < −1 −2 −3 < −2 −1 < Med  
 Wt for age z score (WAZ) (under Wt = < −2 SD) −2 SD −2 SD < −1 SD −2 SD −1 < Median −3 < −2 −3 < −2 −3  
 TPHA titers (1:8) 1:4 1:32  
FBC
 Hemoglobin (10.5–14 g/dL) 7.0 7.1 10.2 9.1    8.2 8.3 (1.4)
 MCV (72–88 fL) 59.7 71.9 66.7 72.9    85.3 71.3 (9.4)
 MCH (24–30 pg) 17.2 18.2 21.3 22.9    26.2 21.2 (3.6)
 WCC (6–14 × 103/μL) 15 10.4 17 14    16.79 14.6 (2.7)
 Platelets (150–450 × 103/μL) 300 594 657 344    255 430 (182.6)
Differential count
 Neutrophils (16–52%) 31 15 23 16    27.4 22.5 (7)
 Lymphocytes (32–69%) 64 72 71 79    55.8 68.4 (8.8)
 Monocytes (2–8%) 2 11 4 3    16.2 7.2 (6.1)
 Eosinophils (0–5%) 3 1 2 2    0.4 1.7 (1)
 Basophils (0–2%) 0 1 0 0    0.2 0.2 (0.4)
  1. CNE, no perinatal HIV exposure—child not exposed; CE, perinatal HIV exposure—child exposed; NR, nonreactive; RTI, respiratory tract infection; SD, standard deviation; TPHA, Treponema pallidum hemagglutination assay
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