TY - JOUR AU - Lipsitt, Amanda E. AU - Hung, Jaclyn Y. AU - Langevin, Anne-Marie PY - 2021 DA - 2021/03/05 TI - Atezolizumab in combination with intrathecal chemotherapy and radiation for treatment of isolated cerebral nervous system relapse in a patient with extranodal NK/T cell lymphoma: a case report JO - Journal of Medical Case Reports SP - 102 VL - 15 IS - 1 AB - Extranodal NK/T cell lymphoma (ENKTL) is an aggressive form of Epstein-Barr virus (EBV)-associated non-Hodgkin’s lymphoma which historically has a poor prognosis. When relapse occurs, particularly in the cerebral nervous system (CNS), survival is rare. The immune checkpoint pathway family of proteins is highly expressed in many human tumors, especially in EBV-related malignancies. To the best of our knowledge, there are no reports of immune checkpoint inhibitors used either alone or in combination for the treatment of ENTKL CNS relapse, yet there are promising results in metastatic CNS involvement of other malignancies. SN - 1752-1947 UR - https://doi.org/10.1186/s13256-021-02740-6 DO - 10.1186/s13256-021-02740-6 ID - Lipsitt2021 ER -