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Table 1 Neurocognitive features of disrupted interhemispheric connectivity in patients with corpus callosotomy and isolated agenesis of the corpus callosum

From: Isolated agenesis of the corpus callosum and normal general intelligence development during postnatal life: a case report and review of the literature

Region of the CCNerve-fiber tractsClinical features in patients with postnatal non-congenital CC lesions (References [11,12,13])Neurocognitive testinga (Reference [14])Cognitive deficiencies in patients with isolated AgCCb (Reference [5])Neuropsychological testingc (References [5, 15])
Genu and rostrumPrefrontalNon-dominant alien hand syndromeTactile Object Recognition test
Hand Pose Imitation test
Inter-Manual Localization of Pressure Points test
Imitation of one-handed transitive and intransitive gestures drawn
Tachistoscopic bilateral visual field matching task
Incoordination of both hand movements
Slow sensory and motor reaction times
Difficult spontaneous memory retrieval
Difficult learning of novel and unfamiliar verbal and visual information
Impaired reasoning, concept formation, and novel complex problem solving
Poor comprehension of sarcasm
Limited interpretation of second-order meanings
Deficient cognitive inhibition and flexibility
Deficient formulation of strategies
Defective application of imagination and creativity
Poor interpretation and expression of emotions according to the social context
Deficient social communication
Wide Range Achievement Test 3 (WRAT-3) for academic skills in the areas of spelling, reading, and arithmetic
6-block and the 10-block versions of the Tactile Performance Test (TPT)
Bimanual Coordination Test (BCT)
Tactual Performance Test
Finger Localization Test
Raven’s Color Progressive Matrices for complex problem solving based on primarily visual/spatial stimuli
Letter and Number Series Tests from the Primary Mental Abilities Test for complex problem solving and inductive reasoning ability
Minnesota Multiphasic Personality Inventory-2 (MMPI-2)
12-item and 40-item free-answer version of the Proverbs Test for abstract verbal comprehension and reasoning
The Thematic Apperception Test (TAT) for recognition of social situations
The Rorschach Inkblot Test for conventional visual recognition and interpretation of ambiguous information
The Child Behavior Checklist (CBCL) for behavioral problems
Body and isthmusPremotorLeft unilateral motor apraxia
Right unilateral constructional apraxia
Impaired rapid alternating movement of both hands
Left hand agraphia
Left tactile anomia
Left auditory anomia
Right olfactory anomia
Supplementary motor
Primary motor
Primary sensory
Parietal lobe
Temporal lobe
SpleniumOccipital lobeLeft hemialexia
Left visual anomia
Pure alexia
Reading words aloud
Word reading
Oral naming of visual presentation
Written naming of visual presentation
  1. aTests used for the evaluation of disconnection interhemispheric syndrome in patients with postnatal lesions of the corpus callosum that may be helpful to reveal neurological deficits in patients with isolated agenesis of the corpus callosum. bThe pattern of cognitive deficiencies may vary between patients with isolated agenesis of the corpus callosum as a result of other clinical factors. cTests used for the screening of neuropsychological deficits in patients with isolated agenesis of the corpus callosum and apparent normal intelligence. Always include the Mini-Mental State Examination, the Wechsler Intelligence Scale for Children, and the Wechsler Adult Intelligence Scale, as well as other validated tests used according to the age and language of the patient. AgCC agenesis of the corpus callosum, CC corpus callosum