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Table 1 Laboratory test results over the hospital stay and at follow-up examinations in an outpatient clinic

From: Thrombotic microangiopathy and liver toxicity due to a combination therapy of leflunomide and methotrexate: a case report

Laboratory parameter (unit)

Normal range

Day −1 at primary hospital

Day 1 at referral clinic

Day 2

Day 3

Day 7

Day 9

Day 14,

dis-charge

Day 37

11 months later

Sodium (mmol/l)

136–146

132

133

135

139

141

145

143

138

137

Potassium (mmol/l)

3.4–4.5

2.9

2.6

2.4

2.4

4.0

3.8

4.2

2.8

4.2

Calcium (mmol/l)

2.2–2.7

NA

1.7

NA

1.7

2.0

1.9

2.1

1.9

2.4

Creatinine (μmol/l)

< 66

108

87

94

67

62

NA

60

60

77

Urea (mmol/l)

3.6–8.0

NA

9.1

8.8

5.5

4.7

NA

2.2

2.5

NA

Cystatin C (mg/l)

0.5–1.0

NA

2.2

2.1

NA

NA

NA

NA

NA

1.6

Lactate dehydrogenase (μmol/l*s)

< 4.12

19.5

9.8

NA

8.2

7.3

7.4

6.8

5.6

NA

Haptoglobin (g/l)

0.3–2.0

NA

< 0.01

NA

NA

NA

NA

NA

NA

NA

Total bilirubin

< 17

19.5

22.0

NA

21.6

NA

NA

NA

23.0

NA

Total serum protein (g/l)

65–85

37.1

34.0

NA

NA

NA

NA

NA

42

81

Serum albumin (g/l)

35–52

NA

17

NA

NA

NA

25

24

21

43

AST (μmol/l*s)

< 0.52

NA

1.3

NA

NA

0.7

NA

0.6

0.8

0.2

ALT (μmol/l*s)

< 0.56

NA

0.7

NA

NA

0.6

NA

0.5

0.2

0.3

gGT (μmol/l*s)

< 0.63

NA

2.1

NA

NA

2.4

 

2.3

1.0

2.4

C-reactive protein (mg/l)

< 5

25.5

27.9

NA

NA

10.9

6.5

11.0

21.3

< 1.0

Complement 3 (g/l)

0.9–1.8

NA

NA

0.6

NA

NA

0.9

NA

NA

NA

Complement 4 (g/l)

0.1–0.4

NA

NA

0.2

NA

NA

0.2

NA

NA

NA

Leukocyte count (Gpt/l)

3.8–9.8

NA

NA

NA

NA

6.7

7.4

5.6

7.9

7.0

Platelet count (Gpt/l)

140–440

NA

97

107

101

94

97

100

96

182

Hemoglobin (mmol/l

7.4–9.9

NA

6.9

6.2

5.6

6.2

6.2

6.4

7.6

9.3

International normalized ratio

0.9–1.2

NA

1.9

2.0

1.6

1.7

1.9

1.4

2.2

NA

  1. ALT alanin-aminotransferase, AST aspartate-aminotransferase, gGT gamma-glutamyltransferase, NA not applicable