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Fig. 3 | Journal of Medical Case Reports

Fig. 3

From: Diagnostically challenging human papillomavirus-associated primary squamous cell carcinoma of the rectum with metastasis in both ovaries: a case report

Fig. 3

Squamous cell carcinoma of the middle rectum. a The tumor involves the mucosal surface and focally displays a tubular growth pattern (arrow) resembling the architecture of adjacent crypts of the normal rectum (arrow). This pattern may be interpreted as an in situ lesion with growth of tumor cells along the basement membranes of the colonic crypts (*). b The invasive tumor component in the submucosa is moderately to poorly differentiated. c The tumor expresses p16. d Shows a positive in situ hybridization result when analyzing for high risk human papillomaviruses

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