From: Respiratory depression in a neonate born to mother on maximum dose sertraline: a case report
Drug | Pharmaco-kinetics | Half life | Time to 99% metabolised [days] | Estimated exposure to parent drug [%] | Estimated exposure to metabolite [%] | Active metabolite [%] | Time to peak concentration [h] |
---|---|---|---|---|---|---|---|
Escitalopran1 | Linear | 27-33 h | 6.1 | 73 | 70 | No | 3-4 |
Fluoxetine | Non-linear | 1-4 days | 25 | 58-73 | 63-71 | Yes | 6-8 |
Sertraline | Linear | 26 h | 5.4 | 29-73 | 29-63% | Yes | 4-10 |