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Table 1 Pharmacokinetics of three most prescribed SSRIs

From: Respiratory depression in a neonate born to mother on maximum dose sertraline: a case report

Drug Pharmaco-kinetics Half life Time to 99% metabolised [days] Estimated exposure to parent drug [%] Estimated exposure to metabolite [%] Active metabolite [%] Time to peak concentration [h]
Escitalopran1 Linear 27-33 h 6.1 73 70 No 3-4
Fluoxetine Non-linear 1-4 days 25 58-73 63-71 Yes 6-8
Sertraline Linear 26 h 5.4 29-73 29-63% Yes 4-10
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