Fig. 1

Clinical course of case 1. Axial computed tomography images corresponding to the timelines of therapy and disease status. Yellow circles indicate the mediastinal lesion, and red circles indicate lung metastatic lesions. a (top) status before treatment with nivolumab. b Regression of both mediastinal and lung metastatic lesions after combination adoptive cell therapy (ACT) and immune checkpoint inhibitor (ICI) therapy. Responses were durable during maintenance therapy with the ICI (c). Black and red arrows indicate ACT and nivolumab administration, respectively (bottom)