Major criteria |
 1. Hb >18.5 g/dL (men)/>16.5 g/dL (women) or Hb or Hct >99th percentile of reference range for age, sex, or altitude of residence or RBC mass >25% above mean normal predicted or Hb >17 g/dL (men)/>15 g/dL (women) if associated with a sustained increase of ≥2 g/dL from baseline that cannot be attributed to correction of iron deficiency |
 2. Presence of JAK2 V617F or JAK2 exon 12 mutation |
Minor criteria |
 1. Trilineage proliferation in Bone Marrow |
 2. Subnormal Erythropoietin level |
 3. Endogenous erythroid colony growth |
 PV diagnosis =2 major criteria and 1 minor criterion OR the first major criterion and 2 minor criteria |