Fig. 1

a Haematoxylin and Eosin (H&E) staining showing medium-sized lymphocytes with rounded nuclei and deeply basophilic cytoplasm with sporadic diffuse large cells entangling necrotic lymphocytes (magnification 40×). b BCL2 staining (magnification 40×). c CD20 staining (magnification 40×). d-e Interphase FISH in false-color display. (d) LSI MYC (8q24)/ IGH (14q32)/ CEP8, tri-color dual-fusion probe showing one fusion (green and red signals together, indicating by yellow arrow) signal and two red (MYC) and green (IGH) non-fused signals, respectively; and two blue signals of centromere 8. (e) LSI BCL2 (18q21) break-apart probe (BAP) showing two co-localization signals (yellow arrows) and one isolated red and green signal (red and green arrows, respectively) f Genome-wide log2 ratio copy number aberration plot (top) and B-allele frequency plot (bottom)