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Table 1 Laboratory data of the patient

From: Pembrolizumab- and ipilimumab-induced diabetic ketoacidosis and isolated adrenocorticotropic hormone deficiency: a case report

Investigation

1 month before admission

This admission

6 months after admission

Reference range

Plasma glucose, mg/dl

87

794

210

70–99

HbA1C, %

N/A

6.5

7.0

4.0–5.6

Beta-hydroxybutyrate, mmol/L

N/A

6.3

N/A

0–0.6

Sodium, mmol/L

135

119

140

136–145

Potassium, mmol/L

3.3

6.5

3.4

3.4–4.5

Chloride, mmol/L

97

82

99

95–105

Bicarbonate, mmol/L

28

13

26

22–29

Anion gap, mmol/L

10

24

15

8–16

Blood urea nitrogen, mg/dl

5

39

N/A

7–20

Creatinine, mg/dl

0.75

1.8

0.82

0.7–1.2

Amylase, U/L

N/A

60

N/A

20–100

Lipase, U/L

N/A

53

N/A

10–60

Anti-GAD, IU/ml

N/A

3.09

N/A

<  17

Anti-IA2, IU/ml

N/A

< 7.5

N/A

<  7.5

C-peptide

N/A

< 0.1

N/A

0.9–7.1

8:00 a.m. cortisol, ng/ml

N/A

0.6

N/A

3–18

ACTH, pg/ml

N/A

21.7

N/A

0–46

FT4, ng/dl

N/A

1.22

1.19

0.8–1.8

TSH, μIU/ml

N/A

2.94

2.560

0.3–4.1

FSH, IU/L

N/A

17.7

13.9

1–8.4

LH, IU/L

N/A

19.4

8.1

1–10.5

Testosterone, nmol/L

N/A

24.46

14.89

5.9–24.7

IGF-1, ng/ml

N/A

N/A

66.4

24.6–269

Prolactin, ng/ml

N/A

15.9

6.7

2–25

  1. Abbreviations: ACTH Adrenocorticotropic hormone, FSH Follicle-stimulating hormone, FT4 Free thyroxine, GAD Glutamic acid decarboxylase, IA2 Islet antigen 2, IGF-1 Insulin-like growth factor 1, LH Luteinizing hormone, N/A Not available, TSH Thyroid-stimulating hormone Boldface define abnormal value
  2. Boldface define abnormal value