Study, year [reference] | Total patients with breast cancer diagnosis | Irradiation dose | Total patients with radiologically induced sarcoma diagnosis (Cahan) | Latency of onset of sarcoma | Location of sarcoma (n) | Type of sarcoma (n) | Mortality due to sarcoma |
---|---|---|---|---|---|---|---|
Blanchard et al., 2002 [14] | 251 Mayo Clinic (USA), 1975–2001 | 50–60 Gy | 34 | 3.3–31 years | ND | Angiosarcoma (12) Malignant fibrous histiocytoma (11) Osteogenic sarcoma (5) Fibroblastic sarcoma (4) Others (2) | 22 (65%) |
Kirova et al., 2005 [16] | 16,705 13,472 RT 3233 without radiotherapy (France), 1981–1997 | 50–55 Gy | 27 | 3–20.3 years | Breast (13) Chest wall (5) Sternum (3) Supraclavicular (2) Scapula (1) Axilla (3) | Angiosarcoma (13) Osteosarcoma (3) Undifferentiated sarcoma (5) Malignant histiocytoma (1) Leiomyosarcoma (2) Fibrosarcoma (1) Rhabdomyosarcoma (1) Myosarcoma (1) | 15 (55.5%) |
Mery et al., 2009 [5] | 563,155 211,027 RT, SEER Registry (USA), 1973–2003 | ND | 146 | 1–29 years | Chest or ipsilateral upper limb | Angiosarcoma (77) Malignant fibrous histiocytoma (16) Leiomyosarcoma (7) Fibrosarcoma (7) Others (39) | OS 38% |
Salminen et al., 2018 [17] | 132,512 Finnish Registry, 1953–2014 | 28–60 Gy | 96 | 0.6–29.9 years | Breast (46) Trunk (16) Scar (11) Shoulder (6) Sternum (5) Axilla (4) Lung (4) Scapula (3) Upper Limb (1) | Angiosarcoma (50) Undifferentiated pleomorphic sarcoma (27) Osteosarcoma (5) Fibrosarcoma (3) Extraskeletal osteosarcoma (3) Chondrosarcoma (2) Leiomyosarcoma (2) Myxofibrosarcoma (2) Extraskeletal Chondrosarcoma (1) Neurofibrosarcoma (1) | 40 (41.6%) |