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Table 1 Drugs for anaplastic astrocytoma targeting patient genetic alterations

From: A deep analysis using panel-based next-generation sequencing in an Ecuadorian pediatric patient with anaplastic astrocytoma: a case report

Target population Drug Drug ID Phase Status Type Mode of action Activity Target Target ID
Adults Sunitinib CHEMBL535 2 Completed Small molecule Inhibitor Antagonist RET ENSG00000165731
Adults Vandetanib CHEMBL24828 2 Completed Small molecule Inhibitor Antagonist RET ENSG00000165731
Adults Sunitinib CHEMBL535 2 Completed Small molecule Inhibitor Antagonist RET ENSG00000165731
Adults Sorafenib CHEMBL1336 1 Completed Small molecule Inhibitor Antagonist RET ENSG00000165731
Adults Sorafenib CHEMBL1336 1 Completed Small molecule Inhibitor Antagonist RET ENSG00000165731
Adults Vandetanib CHEMBL24828 2 Completed Small molecule Inhibitor Antagonist EGFR ENSG00000146648
Adults Erlotinib CHEMBL553 1 Completed Small molecule Inhibitor Antagonist EGFR ENSG00000146648
Adults Erlotinib CHEMBL553 1 Completed Small molecule Inhibitor Antagonist EGFR ENSG00000146648
Adults Erlotinib CHEMBL553 1 Completed Small molecule Inhibitor Antagonist EGFR ENSG00000146648
Adults Cetuximab CHEMBL1201577 1 Completed Antibody Inhibitor Antagonist EGFR ENSG00000146648
Adults Erlotinib CHEMBL553 1 Terminated Small molecule Inhibitor Antagonist EGFR ENSG00000146648
Children Cabozantinib CHEMBL2105717 2 Recruiting Small molecule Inhibitor Antagonist MET ENSG00000105976
Children Ribociclib CHEMBL3545110 1 Recruiting Small molecule Inhibitor Antagonist CDK4 ENSG00000135446