Intraovarian injection of autologous human mesenchymal stem cells increases estrogen production and reduces menopausal symptoms in women with premature ovarian failure: two case reports and a review of the literature

Table 2 Hormone levels prior to and 12 months after mesenchymal stem cell injection into the right ovary

	Reference range	Preoperative		1 week		1 month		3 months		6 months		9 months		12 months
	Reference range	P1	P2	P1	P2	P1	P2	P1	P2	P1	P2	P1	P2	P1	P2
AMH	(1.1–53.5 ng/ml)	< 0.0140	< 0.015	0.0140	< 0.015	< 0.0140	< 0.015	< 0.014	< 0.015	< 0.1	*	< 0.0140	< 0.015	< 0.1	*
FSH	(3.0–8.0 IU/L)	89.4	150.8	132	161.4	91.2	149.9	78.1	147.1	68.5	*	89.2	150.1	80.3	*
LH	(2.0–12.0 IU/L)	45.8	67.0	48.3	69.5	36.3	75.2	37.3	67.8	41.4	*	45.0	71.0	41.3	*
CA 125	< 36 kU/L	11	10.2	13	20.6	13	12.0	11	10.6	2.9	*		12.3		*
Estradiol	(27–123 pg/ml)	< 10.896	*	19.88	< 5.0	14.165	< 5.0	< 10.9	< 5.0	26.15	*	21.79	10.9	19.3	*
Progesterone	(0.1–0.7 ng/ml)	0.1887	0.5		0.2	0.2201	< 0.1	< 0.16	< 0.1	< 0.157	*	0.2201	< 0.1	*	*

Abbreviations: AMH Anti-Müllerian hormone, CA 125 Cancer antigen 125, FSH Follicle-stimulating hormone, LH Luteinizing hormone, P1 Patient #1, P2 Patient #2
*Data not available

ISSN: 1752-1947