Table 1 Timeline of case 1
Timeline | Description of the presentation and follow-up | Duration of topical medication and ulcer resolution |
|---|---|---|
Day 1 | Patient with grade 2 shield ulcer in the right eye. Treatment with prednisolone acetate 1% twice daily and epinastine hydrochloride 0.05 mg/ml eye drops twice daily | Start of assistance with topical medication |
Day 7 | No improvement in the shield ulcer | Maintenance of topical medication |
Day 28 | Slight reduction in the shield ulcer. Surgical removal of the plaque was indicated. Lost contact with the patient | After 28 days, the assistance was interrupted for 104 days |
Day 118 | Return of the patient. Treatment with prednisolone acetate 1% twice daily and epinastine hydrochloride 0.05 mg/ml eye drops twice daily | Restart of topical medication for 14 days prior to surgery |
Day 132 | Surgical debridement was performed. Occlusive dressing with ciprofloxacin hydrochloride ointment (3.5 mg/g) and dexamethasone (1.0 mg/g) was applied for a week | New topical medication for 7 days after surgery and ulcer resolution in this period |
Day 139 | Completely re-epithelialized cornea with a diffuse anterior stromal haze. Treatment with prednisolone acetate 1% every 2 days in both eyes and epinastine hydrochloride 0.05% twice daily | Topical treatment changed and maintained for 45 days |
Day 184 | Diffuse anterior stromal haze in the area of the previous ulcer. Treatment with tacrolimus 0.02% twice daily in both eyes and epinastine hydrochloride 0.05% twice daily in both eyes | Topical medication maintained for another 2 months |
Month 8 | Diffuse anterior stromal haze, with no signs of ulcer. Clinical treatment maintained | Topical treatment maintained |