Hepatitis C virus relapse after successful treatment with direct-acting antivirals, followed by sarcomatous changes in hepatocellular carcinoma: a case report

Table 1 Five cases showing sarcomatous changes in hepatocellular carcinoma

Case	Age (years)	Sex	Background	HCV Ab	AFP (ng/ml)	PIVKA-II (mAU/ml)	Central necrosis	Extrahepatic growth	Distant metastasis	Treatment before sarcomatous change
1	81	Male	Chronic hepatitis	+	n.a.	n.a.	–	+	+	PEIT
2	66	Male	Liver cirrhosis	+	756	39,700	+	+	+	TAE
3	74	Female	Liver cirrhosis	+	4.4	20	+	+	+	RFA
4	83	Female	Liver cirrhosis	+	5926	14	–	–	+	RFA, TACE
Our patient	74	Male	Liver cirrhosis	+	2.3	19	+	+	+	RFA

Abbreviations: AFP α-Fetoprotein, n.a. Not available, PEIT Percutaneous ethanol injection therapy, PIVKA-II Protein induced by vitamin K absence/antagonist-II, RFA Radiofrequency ablation, TACE Transcatheter arterial chemoembolization, TAE Transcatheter arterial embolization
Five cases with sarcomatous changes, including our patient’s case, have been observed at autopsy at our institute

ISSN: 1752-1947