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Table 3 Lymphocyte, memory B-cell populations, and serology

From: Enhanced serum immunoglobulin G clearance in myotonic dystrophy-associated hypogammaglobulinemia: a case series and review of the literature

a)

 

Patient II-1

Patient III-1

Reference range

Lymphocyte count (cells × 109/L)

1.9

1.1

1.2–2.7

CD3+ (%)

86

78

49–84

CD3+ (cells × 109/L)

1.63

0.86

0.6–2.99

CD19+ (%)

6

10

7–27

CD19+ (cells × 109/L)

0.11

0.11

0.11–0.7

CD4+ (%)

43

55

28–63

CD4+ (cells × 109/L)

0.82

0.6

0.44–2.16

CD8+ (%)

40

20

10–40

CD8+ (cells × 109/L)

0.76

0.22

0.13–1.31

CD16+CD56+ (%)

7

11

4–25

CD16+CD56+ (cells × 109/L)

0.13

0.12

0.1–0.64

CD4+:CD8+ ratio

1.08

2.75

0.6–5

b)

 

Patient II-1

Patient III-1

Reference rangea

Total CD19+ B cells (% of lymphocytes)

4.9

7.8

5–26

Total CD19+ B cells (cells × 109/L)

0.093

0.086

58–558

CD19+ 27+ memory B cells (% of B cells)

41

11

7–48

CD19+ 27+ memory B cells (cells × 109/L)

0.038

0.0097

0.013–0.148

CD19+ 27+IgM−IgD− switched memory B cells (% of B cells)

35

5.8

3–23

CD19+ 27+IgM−IgD−switched memory B cells (cells × 109/L)

0.032

0.0050

0.004–0.066

CD19+ 27−IgM+IgD+naïve B cells (% of B cells)

55

87

29–93

c)

 

Patient II-1

Patient III-1

Reference range

Diphtheria IgG (IU/mL)

0.26

n.d.

> 0.1

Haemophilus influenzae IgG

0.47

n.d.

N/A

Pneumococcal IgG (mcg/mL)

7.5

16.9

> 39

Tetanus IgG (IU/mL)

2.59

0.84

> 0.16

  1. IgG immunoglobulin G. aBased on published data. Abnormal results are shown in bold