Table 3 Characteristics of studies examining antipyretic effects of diclofenac in the intensive care unit
No. of participants | Dose | Administration route | Infusion duration | Side effects | |
|---|---|---|---|---|---|
Zandstra et al. [10], 1983 | 7 | 100 mg | Rectal | NA | Arterial hypotension, oliguria |
Pesenti et al. [11], 1986 | 10 | 0.2 mg/kg | Intravenous | 5 minutes | – |
Cormio et al. [12], 2000 | 12 | 0.04 mg/kg/hour | Intravenous | 48 hours | – |
Caricato et al. [13], 2004 | 18 | 0.04 mg/kg/hour | Intravenous | ≥ 24 hours | Reduction in MAP |
Cormio et al. [14], 2004 | 35 | 0.17 mg/kg | Subcutaneous | NA | – |
Cormio et al. [15], 2007 | 22 | 0.2 mg/kg (bolus); 0.002–0.08 mg/kg/h (infusion) | Intravenous | Bolus: 30 min Infusion: 6.6 ± 2.3 days | – |
Schiefecker et al. [16], 2013 | 21 | 75 mg | Intravenous | 30 min | Reduction in MAP, CPP and PbtO2 |
Picetti et al. [17], 2016 | 30 | 12.5 mg | Intramuscular | NA | Reduction in HR, MAP, and CPP |