Question | Yes | No | Do not know | Score |
---|---|---|---|---|
Are there previous conclusive reports on this reaction? | +1 | 0 | 0 | +1 |
Did the adverse event appear after the suspected drug was administered? | +2 | −1 | 0 | +2 |
Did the adverse reaction improve when the drug was discontinued or a specific antagonist was administered? | +1 | 0 | 0 | +1 |
Did the adverse event reappear when the drug was readministered? | +2 | −1 | 0 | +2 |
Are there alternative causes (other than the drug) that could on their own have caused the reaction? | −1 | +2 | 0 | +2 |
Did the reaction reappear when a placebo was given? | −1 | +1 | 0 | 0 |
Was the drug detected in blood (or other fluids) in concentrations known to be toxic? | +1 | 0 | 0 | 0 |
Was the reaction more severe when the dose was increased or less severe when the dose was decreased? | +1 | 0 | 0 | 0 |
Did the patient have a similar reaction to the same or similar drugs in any previous exposure? | +1 | 0 | 0 | 0 |
Was the adverse event confirmed by any objective evidence? | +1 | 0 | 0 | 0 |
Total score | Â | Â | Â | 8 |