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Table 2 Naranjo Adverse Drug Reaction Probability Scale scoring system

From: Levothyroxine-induced liver injury followed by complete recovery upon cessation of the drug: a case report

Question

Yes

No

Do not know

Score

Are there previous conclusive reports on this reaction?

+1

0

0

+1

Did the adverse event appear after the suspected drug was administered?

+2

−1

0

+2

Did the adverse reaction improve when the drug was discontinued or a specific antagonist was administered?

+1

0

0

+1

Did the adverse event reappear when the drug was readministered?

+2

−1

0

+2

Are there alternative causes (other than the drug) that could on their own have caused the reaction?

−1

+2

0

+2

Did the reaction reappear when a placebo was given?

−1

+1

0

0

Was the drug detected in blood (or other fluids) in concentrations known to be toxic?

+1

0

0

0

Was the reaction more severe when the dose was increased or less severe when the dose was decreased?

+1

0

0

0

Did the patient have a similar reaction to the same or similar drugs in any previous exposure?

+1

0

0

0

Was the adverse event confirmed by any objective evidence?

+1

0

0

0

Total score

   

8