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Table 1 Differential diagnosis of papillary lesions of the cervix

From: Papillary squamotransitional cell carcinoma of the uterine cervix: a case report and review of the literature

Benign Malignant
Condyloma acuminatum Warty squamous cell carcinoma
Squamous papilloma Verrucous carcinoma
Cervical intraepithelial neoplasia with papillary
configuration
Transitional cell carcinoma of the endometrium and endometrial adenocarcinoma
Papillary adenofibroma Villoglandular papillary adenocarcinoma
  1. Papillary squamotransitional cell carcinomas of the uterine cervix (PSTCC) have a papillary protrusion bulging with fibrovascular cores under a few layers of atypical epithelial cells, resembling a high-grade squamous intraepithelial lesion of the cervix. Condylomata and papillomas present an endophytic growth pattern with trabeculae of transitional cells and anastomosing cords. To differentiate these lesions, mitotic activity, cellularity, and cytologic atypia expression, which increase in the case of PSTCC, are examined [14, 17]