Fig. 2

Computed tomography findings during therapeutic courses. a, b New metastases such as pleura, diaphragm, and the right paracolic gutter appeared after sunitinib treatment. c, d The metastases diminished in size and lung metastases maintained shrinking state after axitinib treatment. e, f The size of metastases increased again after discontinuation of axitinib. g, h Existing metastatic lesions were growing, peritoneal dissemination appeared in the pelvic region, and pleural effusion appeared after nivolumab treatment. i, j Metastases such as lung, pleura, diaphragm, and the right paracolic gutter diminished in size after low-dose axitinib (2 mg/day) treatment