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Table 1 Characteristics and risks related to overdose of the drugs implicated in this case

From: Endoscopic removal of a gastric pharmacobezoar induced by clomipramine, lorazepam, and domperidone overdose: a case report

Drug name Maximal oral daily dosing (adult) 1 Half-life (adult) Intoxication signs (non-exhaustive list) 2 Risk factors for bezoar’s formation in the reported case
Clomipramine 250 mg/d • Clomipramine: 19 - 37 h
• Desmethylclomipramine (active metabolite): 54 – 77 h
• Tachycardia, hypotension, orthostasis
• PR, QRS, QTc intervals prolongation
• Anticholinergic effects (e.g. blurred vision, delirium, agitation, hallucinations, mydriasis, sinus tachycardia, urinary retention)
• Seizures, sedation
• Anticholinergic effect
• Sustained-release formulation with hypromellose component
• Massive tablets ingestion (i.e. 115 tablets, 8,625 g)
Domperidone 30 mg/d ~ 7 h • QT interval prolongation, cardiac arrhythmia
• Restlessness, drowsiness, insomnia, headache, confusion, dizziness and acute dystonic reactions, akathisia, parkinsonian-like symptoms
• Diarrhea, dry mouth
• Massive tablet ingestion (i.e. 16 tablets, 160 mg)
Lorazepam 10 mg/d ~ 12 h • Sedation, dizziness, amnesia, ataxia, slurred speech, lethargy
• Hypotension
• Hypothermia, respiratory failure
• Coma
• Massive tablet ingestion (i.e. 50 tablets, 125 mg)
  1. References:
  2. [1] Lexicomp mobile software, Lexi-Drugs, Hudson, Ohio: Wolters Kluwer Clinical Drug Information, Inc., July 14, 2016
  3. [2] Lexicomp mobile software, Lexi-Tox, Hudson, Ohio: Wolters Kluwer Clinical Drug Information, Inc., July 14, 2016