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Table 1 Reported cases with development of ischemic stroke after intravenous immunoglobulin therapy

From: A serious thrombotic event in a patient with immune thrombocytopenia requiring intravenous immunoglobulin: a case report

References Age/sex Underlying disease Baseline platelet count (×109/L) Indication for IVIg therapy IVIg dosage Duration between time of IVIg initiation and ischemic stroke occurrence Brain imaging findings Outcomes
Sztajzel 1999 [10] 46-year-old female Guillain-Barré syndrome NR Severe polyradiculoneuropathy 0.4 g/kg/day for 5 days 5 days Bilateral hypodensities in the capsulolenticular regions Motor full recovery, but memory difficulties and impairment of the executive functions
Alexandrescu 2005 [9] 82-year-old male CIDP 190 Monthly IVIg administration for CIDP treatment (previously treated with IVIg of 86 doses without any adverse reactions) 50 g, single dose Several hours Large frontoparietal infarct involving the white and gray matter and basal ganglia, without hemorrhage Partial recovery
Milani 2009 [8] 55-year-old male Chronic lymphocytic leukemia 170 Hypogammaglobulinemia (previously tolerated multiple infusions of IVIg without any adverse reactions) 0.4 g/kg (30 g), single dose 12 hours Cerebral infarcts seen within the left posterior middle cerebral artery distribution, bilateral high parietal loops, and bilateral occipital lobes Deceased
Chang 2014 [13] 44-year-old male Miller Fisher syndrome NR Miller Fisher syndrome treatment 0.4 g/kg/day for 5 days, total 180 g 3 weeks Acute left parieto-occipital infarct with hemorrhagic transformation and perilesional edema Partial recovery
Our patient 49-year-old female ITP, DM, HT, hyperthyroidism 3 Active ITP with large hematoma at right buttock 1 g/kg/day (60 g), single dose 12 hours Extensive acute ischemic changed and hemorrhagic transformation in bilateral asymmetrical cerebral white matter as well as left basal ganglion and cerebral peduncle Deceased
  1. Abbreviations: CIDP Chronic inflammatory demyelinating polyneuropathy, DM Diabetes mellitus, HT Hypertension, ITP Immune thrombocytopenia, IVIg Intravenous immunoglobulin, NR Not reported
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