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Table 1 Previous publications demonstrating diffuse large B-cell lymphoma spontaneous remission

From: Spontaneous remission in diffuse large cell lymphoma: a case report

Case Age/sex Site Size Staging CD10 MUM-1a B
C L-6b
BCL-2c COOd Additional findings Time to SRe (days) Type of response Additional treatment Response duration (months) Outcome Ref
1 88/F LN × 1 Neck 4 cm I + NA NA NA NA NA 105 CR None 21 Remission Case
2 72/F Leg 3 cm I + NA + ABCf EBV-h (intra-tumor CD3, CD4 and CD8 + cells observed) NA r PRj None 21 Remission 4
3 66/F Tongue 2 × 1 cm I + + ABC EBV − 180 CRk None 84 Remission 5
4 71/F Breast 2.6 cm I + + + ABC EBV − 30 CR None 18 Remission 6
5 2/M Mastoid Tumor fills sinus cavity I NA + ABC EBV + 40 CR None 24 Remission 7
6 60/F Gastric 1–2 cm I NA NA NA NA H. pylori + i EBV − 139 CR Anti-H. pylori m 15 Remission 8
7 61/M Gastric 2 cm I NA NA NA NA H. pylori + EBV − 75 CR Roxatidine 6 Remission 8
8 73/F Gastric NA I NA NA NA NA NA H. pylori + 40 CR Anti-H. pylori n 30 Remission 9
9 67/F Max. sinus 5.1 × 4.2 cm I + + + + ABC p EBV − 240 CR None 12 Remission 10
10 61/F Spleen Tumor diffusely infiltrated spleen I +   + ABC EBV + 15 CR Prednisone o 27 Patient relapsed requiring chemotherapy 27 months after diagnosis 2
11 40/F Orbit/Conjunctiva NA I NA NA NA NA NA EBV + 40 CR None 6 Remission 11
12 70/M Jaw   I NA NA NA NA NA NA 20 CR None 18 Remission 12
13 82/F Leg Multiple 2 cm lesions II + + + ABC EBV − 30 CR None 4 (Stroke)✝ 13
14 85/M LN × 3. 0.5–2 cm II NA NA NA + NA EBV − 30 CR None 3 (Pneumonia)✝ 14
15 94/F LN × 3 1–2 cm III NA NA NA NA NA EBV + 90 CR None 10 (Pneumonia)✝ 15
16 89/M LN × 2 4 cm III-IV + NA ABC EBV + 60 CR None 20 (Pneumonia)✝ 16
17 85/M Prostate Tumor diffusely involved prostate III-IV NA NA NA NA NA NA NA CR None 31 CR 17
  1. aMUM-1 multiple myeloma-1, b BCL-6 B cell lymphoma-6, c BCL-2 B cell lymphoma-2, d COO cell of origin, e SR spontaneous remission, f ABC activated B-cell, h EBV Epstein–Barr virus, i H. pylori Helicobacter pylori, j PR partial remission, k CR complete remission; l, m anti-H. pylori therapy 1 week of lansoprazole/amoxicillin/clarithromycin, n anti-H. pylori therapy 6 weeks of lansoprazole/amoxicillin/clarithromycin, o prednisone patient received steroid therapy for hemophagocytic syndrome (HPS) at 15 months and 21 months without evidence of lymphoma recurrence, p suspected COO ABC given MUM-1 and BCL-6 positive status, F female, LN lymph node, M male, r NA not available, deceased