Intravenously administered cloxacillin-induced neutropenia with eosinophilia in a patient with infective endocarditis: a case report

Table 1 Timeline: fluctuation of hematological parameters, inflammatory markers, and transthoracic two-dimensional echocardiography following intravenously administered cloxacillin treatment

	Timeline
Parameter	On IV cloxacillin therapy				Omission of IV cloxacillin
Hematological	On admission	Day ₁₂	Day ₁₇	Day ₂₂	Day ₂₄	Day ₂₆	Day ₃₀	Day ₃₂	Day ₃₄
WBC/mm³	12.4	8.2	8.1	3.5	2.5	3.1	4.2	4.4	4.4
N (%)	81	70	65	59	34	41	44	40	50
E (%)	1	1	1	6	22	22	18	18	9
Hemoglobin (g/dL)	11.2	10.9	10.8	10.0	9.5	10.1	10.9	10.9	10.0
Platelets (10⁶/mm³)	219	430	400	293	202	208	281	302	290
Inflammatory
CRP (mg/l)	231	56	29	16	78	102	68	32	8
ESR mm/first hour	100	95	88	68	95	90	78	70	56
Transthoracic two-dimensional echo
Vegetation	Yes	Yes	Yes	Yes	No	No	No	No	No
Size (mm)	7 × 13	7 × 10	6 × 10	4 × 8	–	–	–	–	–

CRP C-reactive protein, E eosinophils, echo echocardiography, ESR erythrocyte sedimentation rate, IV intravenously administered, N neutrophils, WBC white blood cells

ISSN: 1752-1947