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Table 1 Biological markers in serum and cerebrospinal fluid

From: Neuromyelitis optica spectrum disorder with increased aquaporin-4 microparticles prior to autoantibodies in cerebrospinal fluid: a case report

Year

Age (years)

Source

AQP4

NFL

CXCL13

CaMK II

D1

D2

MOG

Alb quota

2012

22

Serum

132

8000

32,000

2012

22

CSF

209

250

250

3.7

2014

24

Serum

1:100

109, 99

Negative

Negative

Negative

2014

24

CSF

Negative

300

44

 

Negative

3.6

2015

25

Serum

1:10

1:32

2015

25

CSF

 

400

167

Negative

4.4

2018

28

Serum

1:10

2018

28

CSF

Negative

370

3

3.1

  1. Abbreviations: Alb quota Ratio between albumin concentration in CSF (mg/L) and serum (g/L) (reference < 6), AQP4 Aquaporin-4 antibody, NMO Neuromyelitis optica (IgG) (reference negative), NFL Neurofilament light protein (reference < 380), CSF Cerebrospinal fluid, CXCL13 Chemokine (C-X-C motif) ligand 13, also known as B-cell-attracting chemokine 1 (BCA-1) (reference < 7.8), CaMK II Ca2+/calmodulin-dependent protein kinase II (positive > 130%), D1 Dopamine receptor antibody positive > 2000, D2 Dopamine 2 receptor antibody positive > 8000, MOG Myelin oligodendrocyte glycoprotein (IgG) (reference negative)
  2. Positive values are presented in bold