Table 2 Clinical features of hypothalamic hypopituitarism secondary to metastasis reported in the literature
Patient | Reference | Age (years) | Sex | Predisposing factor | Primary disease | Symptoms | Diabetes insipidus | Metastases | Therapy | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|
1 | 8 | 50 | Female | Breast cancer | Breast cancer | Lethargy, body weight gain, memory loss | No | Bone | Hormone replacement therapy | Died some weeks later |
2 | 9 | 58 | Male | Heavy cigarette smoker, alcohol abuse | Small cell lung cancer | Lethargy, body weight loss, decreased libido, diarrhea, cold intolerance | Yes | Cerebral, liver, adrenal grand | Hormone replacement therapy, radiation, chemotherapy | Died 9 month later |
3 | 10 | 73 | Male | Heavy cigarette smoker (1pack for 50 years) | Small cell lung cancer | Lethargy, loss of appetite, neck swelling, cough | Yes | Cerebral | Hormone replacement therapy, radiation, chemotherapy | Died 10 month later |
4 | 11 | 47 | Male | Not described | Stomach cancer | Diabetes insipidus | Yes | Abdominal node, cerebral | Not described | Not described |
5 | 11 | 52 | Female | Not described | Breast cancer | Diabetes insipidus | Yes | Liver | Not described | Not described |
6 | 11 | 54 | Female | Not described | Breast cancer | Diabetes insipidus | Yes | Lung | Not described | Not described |
7 | 11 | 76 | Male | Not described | Lung cancer | Hypopituitarism | Yes | Cerebral | Not described | Not described |
8 | 11 | 37 | Female | Not described | Breast cancer | Diabetes insipidus | Yes | Bone | Not described | Not described |
9 | 11 | 60 | Male | Not described | Lung cancer | Neurologic deficit, hypoadrenalism | No | Cerebral | Not described | Not described |
10 | Our case | 67 | Male | Diabetes mellitus, hypertension, angina, heavy smoker (a half a pack for 47 years) | Small cell lung cancer | Lethargy, loss of appetite, body weight loss, generalized weakness, cold intolerance | No | Cerebral | Hormone replacement therapy, radiation, chemotherapy | Died 10 month later |