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Table 1 Laboratory data before and after bortezomib, lenalidomide, and dexamethasone treatment

From: Multiple myeloma presenting as cutaneous leukocytoclastic vasculitis and eosinophilia disclosing a T helper type 1/T helper type 2 imbalance: a case report

  (Normal range) Before After one course of VRD After four courses of VRD After eight courses of VRD
WBC (×109/L) (4–7) 23.3 5.4 6.1 4.3
 neutrophil (× 109/L) (3.9–6) 9 4.1 3.4 2.1
 eosinophil (×109/L) (0.2–0.4) 13.5 0.2 0.2 0.1
 basophil (×109/L) (< 0.1) 0 0 0 0
 lymphocyte (×109/L) (3.5–4) 0.5 1 1.7 1.6
 monocyte (×109/L) (0.2–0.7) 0.3 0.1 0.8 0.6
RBC (×1010/L) (380–500) 299 305 302 331
Hb (g/dl) (12–16) 9.2 10.6 9.7 10.7
Plt (×109/L) (15–40) 152 286 195 197
Total protein (g/dL) (6.9–8.2) 8.2 7.6 6.2 7
Albumin (g/dL) (3.9–4.9) 2.16 3.3 3.8 3.9
LDH (IU/L) (106–211) 280 204 140 160
AST (U/L) (5–40) 50 15 10 15
ALT (U/L) (5–35) 40 12 9 10
ALP (U/L) (104–338) 1564 332 231 319
BUN (mg/dL) (8–20) 47 17 23 20
Creatinine (mg/dL) (0.4–0.8) 2.1 0.82 0.93 1.1
CRP (mg/dL) (< 0.3) 6.6 0.13 0.03 0.04
CH50 (U/mL) (31.6–57.6) < 10 57.8 53.8 78.8
C3 (mg/dL) (65–135) 17.2 81.4 91.9 113.3
C4 (mg/dL) (13–35) 0 19 14.4 22.2
C1q (μg/ml) (< 3) 8.2 < 1.5 < 1.5 < 1.5
Serum β2-microglobulin (μg/dl) (< 2.0) 13.5 2.4 3.2 3
Serum immunoglobulin (Ig)
 IgG (g/dL) (8.7–17) 43.8 13.2 11.5 1219
 IgA (mg/dL) (110–410) 96 114 112 184
 IgM (mg/dL) (35–220) 30 48 48 45
 IgE (IU/mL) (10–340) 2455 218 201 196
 κ-light chain (mg/dL) (3.3–19.4) 515 24.2 32.6 25.3
 λ-light chain (mg/dL) (5.7–26.3) 400 17.7 28 18.2
IFN-γ (IU/ml) (<  0.1) < 0.1 6.5 6.7 6.4
IL-4 (pg/mL) (< 6) 50.3 < 6 < 6 < 6
IL-5 (pg/mL) (< 3.9) 56.1 < 3.9 < 3.9 < 3.9
IL-6 (pg/mL) (< 4) 76.2 3.4 < 4 < 4
IL-3 (pg/mL) (< 31) 31 ND ND ND
IL-10 (pg/mL) (< 5) 45 < 5 < 5 < 5
GM-CSF (pg/mL) (< 8) < 8 ND ND ND
TGF-β (ng/mL) (1.56–0.24) 8.74 0.48 0.5 0.52
  1. ALP alkaline phosphatase, ALT alanine transaminase, AST aspartate transaminase, BUN blood urea nitrogen, CRP C-reactive protein, GM-CSF granulocyte-macrophage colony-stimulating factor, Hb hemoglobin, IFN-γ interferon, IgA immunoglobulin A, IgE immunoglobulin E, IgG immunoglobulin G, IgM immunoglobulin M, IL interleukin, LDH lactate dehydrogenase, ND not done, Plt platelets, RBC red blood cells, TGF-β tumor growth factor-β, VRD bortezomib, lenalidomide, and dexamethasone, WBC white blood cells