Table 1 Laboratory data before and after bortezomib, lenalidomide, and dexamethasone treatment
(Normal range) | Before | After one course of VRD | After four courses of VRD | After eight courses of VRD | |
|---|---|---|---|---|---|
WBC (×109/L) | (4–7) | 23.3 | 5.4 | 6.1 | 4.3 |
neutrophil (× 109/L) | (3.9–6) | 9 | 4.1 | 3.4 | 2.1 |
eosinophil (×109/L) | (0.2–0.4) | 13.5 | 0.2 | 0.2 | 0.1 |
basophil (×109/L) | (< 0.1) | 0 | 0 | 0 | 0 |
lymphocyte (×109/L) | (3.5–4) | 0.5 | 1 | 1.7 | 1.6 |
monocyte (×109/L) | (0.2–0.7) | 0.3 | 0.1 | 0.8 | 0.6 |
RBC (×1010/L) | (380–500) | 299 | 305 | 302 | 331 |
Hb (g/dl) | (12–16) | 9.2 | 10.6 | 9.7 | 10.7 |
Plt (×109/L) | (15–40) | 152 | 286 | 195 | 197 |
Total protein (g/dL) | (6.9–8.2) | 8.2 | 7.6 | 6.2 | 7 |
Albumin (g/dL) | (3.9–4.9) | 2.16 | 3.3 | 3.8 | 3.9 |
LDH (IU/L) | (106–211) | 280 | 204 | 140 | 160 |
AST (U/L) | (5–40) | 50 | 15 | 10 | 15 |
ALT (U/L) | (5–35) | 40 | 12 | 9 | 10 |
ALP (U/L) | (104–338) | 1564 | 332 | 231 | 319 |
BUN (mg/dL) | (8–20) | 47 | 17 | 23 | 20 |
Creatinine (mg/dL) | (0.4–0.8) | 2.1 | 0.82 | 0.93 | 1.1 |
CRP (mg/dL) | (< 0.3) | 6.6 | 0.13 | 0.03 | 0.04 |
CH50 (U/mL) | (31.6–57.6) | < 10 | 57.8 | 53.8 | 78.8 |
C3 (mg/dL) | (65–135) | 17.2 | 81.4 | 91.9 | 113.3 |
C4 (mg/dL) | (13–35) | 0 | 19 | 14.4 | 22.2 |
C1q (μg/ml) | (< 3) | 8.2 | < 1.5 | < 1.5 | < 1.5 |
Serum β2-microglobulin (μg/dl) | (< 2.0) | 13.5 | 2.4 | 3.2 | 3 |
Serum immunoglobulin (Ig) | |||||
IgG (g/dL) | (8.7–17) | 43.8 | 13.2 | 11.5 | 1219 |
IgA (mg/dL) | (110–410) | 96 | 114 | 112 | 184 |
IgM (mg/dL) | (35–220) | 30 | 48 | 48 | 45 |
IgE (IU/mL) | (10–340) | 2455 | 218 | 201 | 196 |
κ-light chain (mg/dL) | (3.3–19.4) | 515 | 24.2 | 32.6 | 25.3 |
λ-light chain (mg/dL) | (5.7–26.3) | 400 | 17.7 | 28 | 18.2 |
IFN-γ (IU/ml) | (< 0.1) | < 0.1 | 6.5 | 6.7 | 6.4 |
IL-4 (pg/mL) | (< 6) | 50.3 | < 6 | < 6 | < 6 |
IL-5 (pg/mL) | (< 3.9) | 56.1 | < 3.9 | < 3.9 | < 3.9 |
IL-6 (pg/mL) | (< 4) | 76.2 | 3.4 | < 4 | < 4 |
IL-3 (pg/mL) | (< 31) | 31 | ND | ND | ND |
IL-10 (pg/mL) | (< 5) | 45 | < 5 | < 5 | < 5 |
GM-CSF (pg/mL) | (< 8) | < 8 | ND | ND | ND |
TGF-β (ng/mL) | (1.56–0.24) | 8.74 | 0.48 | 0.5 | 0.52 |