Fig. 5

Microscopic examination of the spleen. a Splenic trabecula disappeared, and some splenic nodules remained. b Red pulp was occupied by a large number of Gaucher cells. c Higher power field (400×) exhibiting diffuse infiltration by foamy macrophages with vacuolated cytoplasm (Gaucher cells). d Immunohistochemical stain CD68 (+). CD68 denotes histocyte. e Lyso (+). Lyso also denotes histiocytic source. f Vim (+). Vim hints at mesenchymal source. (g). Ki-67 (+<5%) indicates proliferative activity. h Specific stain periodic acid–Schiff (−) ruling out mucus