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Table 2 Additional laboratory investigation findings of the patient

From: Acquired thrombotic thrombocytopenia purpura associated with severe ADAMTS13 deficiency in a 3-year-old boy: a case report and review of the literature

Investigations 17/10/16 20/10/16 11/11/16 14/11/16 14/02/17
Blood culture and sensitivity No growth     
Dengue NS1 antigen Non-reactive     
Dengue IgM Negative     
Dengue IgG Negative     
Mycoplasma pneumoniae IgM Negative     
Mycoplasma pneumoniae IgG 1/80     
Epstein–Barr virus IgM Negative     
Epstein–Barr virus IgG Positive     
Parvovirus IgM Negative     
Parvovirus IgG Negative     
RPR/VDRL     Non-reactive  
HBsAg     Non-reactive  
Anti-HCV     Non-reactive  
HIV antigen and antibody     Non-reactive  
Complement 3 (mg/dL) (NR, 39–180)   109    136
Complement 4 (mg/dL) (NR, 10–40)   18.4    18.7
Anti-nuclear antibody (ELISA)   Positive    Positive
Anti-nuclear antibody (IF)   Positive (1/640)
Pattern: speckled
   Positive (1/640)
Pattern: speckled
Anti-double-stranded DNA (ELISA)   Negative    Borderline
Immunoglobulin A (mg/dL) (NR, 70–400)   187    
Immunoglobulin M (mg/dL) (NR, 40–230)   87.2    
Immunoglobulin G (mg/dL) (NR, 700–1600)   1600    
Direct Coombs test   Negative    
Indirect Coombs test   Negative    
Erythrocyte sedimentation rate (mm/hour)    115   
Prothrombin time (seconds) (NR, 11.9–14.0)    14.2   13.7
Thrombin time (seconds) (NR, 12–21)    16.7   16.1
Fibrinogen (g/L) (NR, 1.36–4.65)    2.58   2.60
PTT LA    48.5   42.4
DRVV screen (seconds) (NR, 28–46.3)    41.7   37.9
DRVV screen ratio    1.04   0.92
Anti-cardiolipin IgM (U/mL) (NR, 0–20)    3.9   
Anti-cardiolipin IgG (U/mL) (NR, 0–20)    9.6   
Anti-beta2 glycoprotein 1 IgM (U/mL) (NR, 0–20)    2.7   1.1
Anti-beta2 glycoprotein 1 IgG (U/mL) (NR, 0–20)    43.5   12.3
Nuclear antibodies
 SmD    Negative   
 RNP-70 K    Negative   
 RNP-A    Negative   
 RNP-C    Negative   
 SSA(Ro52)    Negative   
 SSA(Ro60)    Negative   
 SSB(La)    Negative   
 Cenp-B    Negative   
 Topo-1(Scl-70)    Negative   
 Ribosomal P    Negative   
 Histone    Negative   
 SmB    Negative   
 Jo-1(HRS)    Negative   
  1. Cenp-B centromere protein B, DRVV dilute Russell’s viper venom test, ELISA enzyme-linked immunosorbent assay, HBsAg hepatitis B surface antigen, HCV hepatitis C virus, HIV human immunodeficiency virus, IF immunofluorescent, Jo-1(HRS) histidyl-tRNA synthetase, NR normal range, NS1 nonstructural protein 1, PTT LA prothrombin time lupus anticoagulant, RNP ribonucleoprotein, RPR/VDRL rapid plasma reagin/Venereal Disease Research Laboratory, Sm Smith protein, SSA(Ro) Sjögren’s syndrome-related antigen A, SSB(La) Sjögren’s syndrome-related antigen B, Topo-1(Scl-70) topoisomerase 1