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Table 2 Additional laboratory investigation findings of the patient

From: Acquired thrombotic thrombocytopenia purpura associated with severe ADAMTS13 deficiency in a 3-year-old boy: a case report and review of the literature

Investigations

17/10/16

20/10/16

11/11/16

14/11/16

14/02/17

Blood culture and sensitivity

No growth

    

Dengue NS1 antigen

Non-reactive

    

Dengue IgM

Negative

    

Dengue IgG

Negative

    

Mycoplasma pneumoniae IgM

Negative

    

Mycoplasma pneumoniae IgG

1/80

    

Epstein–Barr virus IgM

Negative

    

Epstein–Barr virus IgG

Positive

    

Parvovirus IgM

Negative

    

Parvovirus IgG

Negative

    

RPR/VDRL

   

Non-reactive

 

HBsAg

   

Non-reactive

 

Anti-HCV

   

Non-reactive

 

HIV antigen and antibody

   

Non-reactive

 

Complement 3 (mg/dL) (NR, 39–180)

 

109

  

136

Complement 4 (mg/dL) (NR, 10–40)

 

18.4

  

18.7

Anti-nuclear antibody (ELISA)

 

Positive

  

Positive

Anti-nuclear antibody (IF)

 

Positive (1/640)

Pattern: speckled

  

Positive (1/640)

Pattern: speckled

Anti-double-stranded DNA (ELISA)

 

Negative

  

Borderline

Immunoglobulin A (mg/dL) (NR, 70–400)

 

187

   

Immunoglobulin M (mg/dL) (NR, 40–230)

 

87.2

   

Immunoglobulin G (mg/dL) (NR, 700–1600)

 

1600

   

Direct Coombs test

 

Negative

   

Indirect Coombs test

 

Negative

   

Erythrocyte sedimentation rate (mm/hour)

  

115

  

Prothrombin time (seconds) (NR, 11.9–14.0)

  

14.2

 

13.7

Thrombin time (seconds) (NR, 12–21)

  

16.7

 

16.1

Fibrinogen (g/L) (NR, 1.36–4.65)

  

2.58

 

2.60

PTT LA

  

48.5

 

42.4

DRVV screen (seconds) (NR, 28–46.3)

  

41.7

 

37.9

DRVV screen ratio

  

1.04

 

0.92

Anti-cardiolipin IgM (U/mL) (NR, 0–20)

  

3.9

  

Anti-cardiolipin IgG (U/mL) (NR, 0–20)

  

9.6

  

Anti-beta2 glycoprotein 1 IgM (U/mL) (NR, 0–20)

  

2.7

 

1.1

Anti-beta2 glycoprotein 1 IgG (U/mL) (NR, 0–20)

  

43.5

 

12.3

Nuclear antibodies

 SmD

  

Negative

  

 RNP-70 K

  

Negative

  

 RNP-A

  

Negative

  

 RNP-C

  

Negative

  

 SSA(Ro52)

  

Negative

  

 SSA(Ro60)

  

Negative

  

 SSB(La)

  

Negative

  

 Cenp-B

  

Negative

  

 Topo-1(Scl-70)

  

Negative

  

 Ribosomal P

  

Negative

  

 Histone

  

Negative

  

 SmB

  

Negative

  

 Jo-1(HRS)

  

Negative

  
  1. Cenp-B centromere protein B, DRVV dilute Russell’s viper venom test, ELISA enzyme-linked immunosorbent assay, HBsAg hepatitis B surface antigen, HCV hepatitis C virus, HIV human immunodeficiency virus, IF immunofluorescent, Jo-1(HRS) histidyl-tRNA synthetase, NR normal range, NS1 nonstructural protein 1, PTT LA prothrombin time lupus anticoagulant, RNP ribonucleoprotein, RPR/VDRL rapid plasma reagin/Venereal Disease Research Laboratory, Sm Smith protein, SSA(Ro) Sjögren’s syndrome-related antigen A, SSB(La) Sjögren’s syndrome-related antigen B, Topo-1(Scl-70) topoisomerase 1