Table 1 Differential diagnosis of grade I (well-differentiated) and grade II (intermediately differentiated) angiosarcomas of the breast
From: Diagnostic difficulties of primary angiosarcoma of the breast: a case report
Lesion | Grade I angiosarcoma | PASH | Hemangioma | Angiomatosis |
Size | Always > 2 cm | Variable | < 2 cm | Diffuse |
Anastomosing spaces | True vascular channels contain erythrocytes | Pseudovascular spaces, without erythrocytes | True vascular channels contain erythrocytes | True vascular channels contain erythrocytes |
Destruction of adjacent breast tissue, invasion of fat | Yes | No | No | No |
Dense hyaline stroma | Absent | Present | Absent | Absent |
Lining cells | Atypical with prominent and hyperchromatic nuclei | Without atypia (very rarely atypia and hyperchromasia) | Without atypia | Without atypia |
Factor VIII and CD31 | Positive | Negative | Positive | Positive |