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Table 2 Apixaban concentration, treatment, and clinical course

From: Activated prothrombin complex concentrate to reverse the factor Xa inhibitor (apixaban) effect before emergency surgery: a case series

  aFXa (μg/L) Time from last apixaban dose to surgery aPCC dose Excessive perioperative or postoperative bleeding Thromboembolic complications
Patient 1 69 24 hours 25 IU/kg No No
Patient 2 152 10 hours 28 IU/kg No No
Patient 3 98 9 hours 29 IU/kg Yes No
  1. aFXa anti-factor Xa activity, aPCC activated prothrombin complex concentrate