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Table 2 Apixaban concentration, treatment, and clinical course

From: Activated prothrombin complex concentrate to reverse the factor Xa inhibitor (apixaban) effect before emergency surgery: a case series

 

aFXa (μg/L)

Time from last apixaban dose to surgery

aPCC dose

Excessive perioperative or postoperative bleeding

Thromboembolic complications

Patient 1

69

24 hours

25 IU/kg

No

No

Patient 2

152

10 hours

28 IU/kg

No

No

Patient 3

98

9 hours

29 IU/kg

Yes

No

  1. aFXa anti-factor Xa activity, aPCC activated prothrombin complex concentrate