Fig. 3

Interphase nucleus fluorescence in situ hybridization and cytogenetic karyotyping images from bone marrow culture at the time of chronic lymphocytic leukemia diagnosis and from peripheral blood at the time of chronic myeloid leukemia diagnosis. a Interphase nucleus probes with CCND1 (Red) and IGH (Green), yellow arrows indicate the presence of one large signal (normal chromosome 11) and two small signals indicate the rearrangement involving other chromosome 11 homolog. b Interphase nucleus probes with chromosome 8 centromere (D8Z1, Green) and chromosome 12 centromere (D12Z1, Red). Arrows indicate the presence of trisomy of chromosome 12. c Interphase nucleus probes for ABL1 gene (on chromosome 9, Red) and BCR gene (on chromosome 22, Green). Arrows indicate BCR/ABL fusion signals. d Cytogenetic karyotyping revealing a male with 46,XY, t(9;22)(q34;q11.2) translocation