Skip to main content

Table 1 Brief summary of regimens used during the whole clinical course

From: A novel combination of bortezomib, lenalidomide, and clarithromycin produced stringent complete response in refractory multiple myeloma complicated with diabetes mellitus – clinical significance and possible mechanisms: a case report

Regimen

Cycles

Date of treatments

FLC-λ(mg/L)/BMG(mg/L)

Evaluation

VAD

3

Jun. 19~Sep.5/2015

≥ 3200→1140/6.5→2.2

Effective

RMdD

1

Sep.14 ~Oct. 4/2015

1140→1430/2.2→2.5

Ineffective

RMdD-CAM400

7

Oct. 12~May 15/2016

1430→439/2.5→1.5

Effective

sdp BD

2

May 16~Jun. 29/2016

439→72.9/1.5→1.3

Effective

BRedD

2

Jul. 11~Sep. 6/2016

72.9→496/1.3→1.5

Ineffective

PD

1

Sep. 13~Oct. 3/2016

496→805/1.5→1.9

Ineffective

sdpBD

1

Oct. 17~Oct. 30/2016

805→267/1.9→1.6

Fairly effective

VAD

1

Nov. 14~Dec. 6/2016

267→323/1.6→1.4

Ineffective

sdpBD-CAM800

2

Dec. 12~Jan. 23/2017

323→24.9/1.4→1.1

Very effective

⑩sdpB-CAM800

1

Feb. 4~Feb. 26/2017

24.9→148/1.1→2.1

Ineffective

⑪ sdpBRMd-cam800

4

Feb. 27~May 8/2017

148→12.9/2.8→2.1

Very effective

⑫ sdpBRedRMd-CAM800

6

May 23~Oct. 31/2017

12.9→14.2/2.1→1.4

Effective/stable

  1. A (ADM) adriamycin, B bortezomib, BMG ß2-microglobulin, CAM clarithromycin, D (Dex) dexamethasone, FLC free light chain, Md minimized-dose, P (Pom) pomalidomide, R Revlimid (Len: lenalidomide), Red reduced dose, sc subcutaneous, sdp short dosing-period, V vincristine, wk week
  2. VAD: V 0.4 mg/body·ADM 9 mg/m2, continuous intravenous infusion, on days 1–4; Dex 40 mg/body, on days1–4, 9–12, 17–20, every 4-wk cycle
  3. RMdD: Len 10 mg/day for 3 wks; Dex 20 mg/day, twice/week for 3 wks, every 4-wk cycle
  4. RMdD-CAM400: RMdD combined with CAM 400 mg/day, 200 mg twice/day for 3 wks, every 4-wk cycle
  5. sdpBD: Bor 1.3 mg/m2, sc, twice/wk for 2 wks; Dex 20 mg/day twice/wk for 2 wks, every 4-wk cycle
  6. BRedD: Bor 1.3 mg/m2, sc, once/wk for 4 wks; Dex 20 mg/day, twice/wk for 4 wks, every 6-wk cycle
  7. PD: Pom 4 mg/day for 3 wks; Dex 20 mg/day twice/wk for 3 wks, every 4-wks cycle
  8. sdpBD VAD
  9. sdpBD-CAM800: sdpBD combined with CAM 800 mg/day, 400 mg twice/day for 2 wks, every 4-wk cycle
  10. ⑩sdpB-CAM800: Bor 1.3 mg/m2, sc, twice/wk for 2 wk; CAM 800 mg/day, 400 mg twice/day for 2 wks, every 4-wk cycle
  11. ⑪sdpBRMd-CAM800: Bor 1.3 mg/m2, sc, twice/wk for 2 wks; Len 10 mg/day for 2 wks; CAM 800 mg/day, 400 mg twice/day for 2 wks, every 4-wk cycle
  12. ⑫sdpBRedRMd-CAM800: Bor 1.3 mg/m2, sc, once/wk for 2 wks; Len 10 mg/day for 2 wks; CAM 800 mg/day, 400 mg twice/day for 2 wks, every 4-wk cycle