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Fig. 4 | Journal of Medical Case Reports

Fig. 4

From: A novel combination of bortezomib, lenalidomide, and clarithromycin produced stringent complete response in refractory multiple myeloma complicated with diabetes mellitus – clinical significance and possible mechanisms: a case report

Fig. 4

Detailed clinical course after September 2016. After the initiation of regimen ⑪ (sdpBRMd-CAM800),  stringent complete response was obtained and is still maintained with regimen ⑫ (sdpBRedRMd-CAM800) as of October 2017. Myeloma cells disappeared from BM and hyperdiploidies also disappeared. Regimen (sdpBD-CAM800) was also effective and the level of FLC-λ was depressed to normal range, but this treatment could not be continued due to aggravation of diabetes mellitus. BD Bor-Dex, BM bone marrow, BR Bor-Revlimid (lenalidomide), CAM clarithromycin, FLC free light chain, Md minimized dose, NCC nucleated cell count, PC plasma cell, PD pomalidomide-Dex, Red reduced dose, sdp short dosing-period, VAD vincristine, adriamycin, and Dex

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