Serious gastric perforation after second stereotactic body radiotherapy for peripheral lung cancer that recurred after initial stereotactic body radiotherapy: a case report

Table 1 Serious toxicities after re-irradiation with stereotactic body radiotherapy for lung tumors in patients previously treated with thoracic radiotherapy

Authors and Reference number	Number of patients	Tumor location (central/peripheral)	Initial irradiation dose^a	Re-SBRT dose^a	Non-lung toxicities of grade 4–5 (tumor location)	Lung toxicities of grade 4–5
Peulen et al. [4]	29	11/21	30 Gy/2 Fr 40 Gy/4 Fr	30 Gy/2 Fr 40 Gy/5 Fr	G5 hemoptysis: 3 pts (central) G4 others^b: 2 pts (central)	None
Liu et al. [6]	72	4/68	63 Gy/Conv	50 Gy/4 Fr	NA	G5 pneumonitis: 1 pt
Reyngold et al. [7]	39	NA	61 Gy/Conv	70.4 Gy (BED₁₀)	G4 skin: 1 pt^c (peripheral)	None
Kilburn et al. [10]	33	17/16	66 Gy/33 Fr 50 Gy/5 Fr	50 Gy/10 Fr	G5 aorta-esophageal fistula: 1 pt (central)	None
Trovo et al. [11]	17	17/0	50–60 Gy/20–30 Fr	30 Gy/5–6 Fr	G5 hemoptysis: 1 pt (central)	G5 pneumonitis: 1 pt
Parks et al. [17]	27	18/11	64.8 Gy/Conv	50 Gy/5 Fr	G4 chest wall pain: 1 pt	None

Abbreviations: BED ₁₀ biologically effective dose (α/β = 10), Conv conventional fractionation, Fr fractions, G grade, NA not available, pt patient, Re-SBRT re-irradiation with stereotactic body radiotherapy
^aMedian dose or frequently used dose
^bVena cava superior stenosis and fistula between the trachea and gastric tube developed in a case with a recurrent tumor at the carina
^cSBRT was performed for a right lung tumor in a patient who had received contralateral lung irradiation [19]

ISSN: 1752-1947