Fig. 1

a Chest computed tomographic scan showing an irregular tumoral lesion of the right breast (circled red arrow). b Positron emission tomographic scan showing a hypermetabolic intramammary lesion with central necrosis (circled red arrow) associated with multiple mediastinal hypermetabolic lymph nodes (yellow arrows). c Breast ultrasound showing a hypoechogenic tumor lesion of 4-cm diameter in the upper external quadrant of the right breast without any spiculation. d Histological specimen (hematoxylin and eosin (H&E) stain, original magnification ×40) showing breast parenchyma massively infiltrated by medium-sized tumor cells with an eosinophilic cytoplasm and an anisokaryotic and hyperchromatic nucleus. The signs of mitosis are moderately frequent. Tumor cells are arranged in massifs or compact and, more rarely, cribriform spans within an abundant fibroinflammatory stroma. Focal areas of Malpighian inflection are observable without any in situ component. e Immunohistochemistry revealing tumor cells that are negative for estrogenic hormone receptors in contrast with normal canal breast cells, which regularly express these receptors (yellow arrow)