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Table 1 Comparison between Bodner and colleagues’ [2] analysis of 116 reported cases of squamous cell carcinoma arising in an odontogenic cyst and the present case

From: Squamous cell carcinoma arising from a keratocystic odontogenic tumor: a case report

Feature Literature review   Present case Comment
Age Mean age 60.2 years 50 years Close to mean age
Commonest age of occurrence 6–8th decades
Gender Male 68% Female Male predilection
Female 36%
Site Mandible 79% Mandible  
Maxilla 21%
Type of cyst Radicular cyst 60% KCOT KCOT malignant transformation rate is rare
Dentigerous cyst 16%
KCOT 14%
Lateral periodontal 1%
Unclassified 9%
Histopathologically Carcinoma in situ 3% Moderately differentiated SCC  
Well-differentiated SCC 45%
Moderately differentiated SCC 40%
Poorly differentiated SCC 7%
Verrucous carcinoma 3%
Spindle cell carcinoma 1%
Signs and symptoms Asymptomatic 11% Mass paresthesia present in the lower lip
Mass 32%
Pain 24%
Painful mass 16%
Jaw expansion 14%
Sensory disturbance 3%
Treatment modality Surgery alone 46% Surgery with neck dissection  
Surgery with radiotherapy 38%
Surgery, radiotherapy with chemotherapy 6%
Surgery with chemotherapy 6%
Radiotherapy alone 4%
Neck dissection 51%
Overall survival 2 years 62% 1.5 years Patient still under review
5 years 28%
  1. KCOT keratocystic odontogenic tumor, SCC squamous cell carcinoma