Fig. 3

Computed tomographic images of the metastatic lymph node during the time course of treatment with regorafenib. The arrows indicate the metastatic lymph node. a Paracaval metastatic lymph node before the beginning of regorafenib therapy. b Metastatic lymph node decreased in size after 4 months of regorafenib therapy. c Metastatic lymph node became indistinguishable after 9 months of regorafenib treatment. d Tumor response was maintained 25 months after the beginning of regorafenib treatment