Previous treatment for Mtb |
Prolonged hospitalization (in Mtb-endemic regions) |
human immunodeficiency virus coinfection |
Inappropriate prescribing of combination ATT (incorrect drug selection, dosing, and improper dispensing) |
Lack of directly observed therapy use during therapy and subsequent patient noncompliance with prescribed therapy |
Lack of sustainable drug availability to patients (for example, second-line drugs for drug-resistant tuberculosis) through an inadequate pharmaceutical supply chain or failure to provide free treatment |
Overuse of fluoroquinolones in other non-Mtb respiratory infection syndromes that propagates fluoroquinolone-resistant Mtb |
Delays in diagnosing drug-resistant Mtb |