1. Hypotension | |
2. Multi-organ involvement characterized by two or more of the following: | |
 Renal impairment | |
 Coagulopathy | |
 Liver involvement | |
 Acute respiratory distress syndrome | |
 A generalized erythematous macular rash that may desquamate | |
 Soft-tissue necrosis, including necrotizing fasciitis or myositis and gangrene | |
Isolation of Streptococcus from | |
 Non-sterile site ⇒ Probable | |
 Normally sterile site ⇒ Confirmed |