Serum cytokine profile in pediatric Sweet’s syndrome: a case report

Table 2 Changes in medical therapy and cytokine levels over 10 weeks

Treatment	Reference range [6, 7]	Pre	1 week	◆	2 weeks	4 weeks	5 weeks	8.5 weeks	10 weeks
PSL (mg/kg per day)		-	2	1		1	2	2	1
Colchicine		-	-	-		-	-	+	+
Antibiotics		-	-	⇒ ⇒ ⇒⇒		⇒ ⇒ ⇒	-	-	-
IL-1β (pg/mL)	<3.2	<0.12	---		---	---	0.66	0.13	0.22
IL-6 (pg/mL)	<5	48	20		---	20	5	8	4
IL-18 (pg/mL)	<500	200	255		---	215	280	193	184
Neopterin (nmol/L)	<5	4.1	5.2		---	5.9	5.1	5.3	7.1
sTNF-RI (pg/mL)	484–1407	1020	1180		---	1860	2320	1150	1260
sTNF-RII (pg/mL)	829–2262	1260	1930		---	2880	3200	1400	2730
CRP (mg/L)	<4	102	23		54	68	8	4	44
ESR (mm/hour)	<10	>160	8		29	29	6	---	7
WBC (/mm³)	5800–16,300	16,170	32,500		35,240	24,730	26,080	21,480	13,860

CRP C-reactive protein, ESR erythrocyte sedimentation rate, IL interleukin, PSL prednisolone, sTNF-RI soluble tumor necrosis factor receptor I, sTNF-RII soluble tumor necrosis factor receptor II, WBC white blood cell
The symbol ‘◆’ represents the onset of the antibiotic therapy performed for urinary tract infections that developed one week after PSL initiation
The symbol ‘⇒’ represents antibiotic therapy for UTI is being performed
The values of pre-treatment are the results just before PSL initiation, and differ from the ones before diagnosis
5 weeks means 5 weeks from the initiation of PSL treatment

ISSN: 1752-1947