Fig. 1

Phosphodiesterase 5 inhibition worsens diastolic function and symptoms of angina in women with ischemic syndrome. Left: Magnetic resonance tissue tagging was performed on two consecutive mid-short axis slices before and after treatment, and analyzed using commercially available software to assess the rate of circumferential strain in diastole. Individual data are shown, illustrating a reduction in all four patients who completed the trial. Group data (mean and standard error) are also reported (black markers). Right: Relationship between changes in self-reported angina frequency (Seattle Angina Questionnaire) and the change in diastolic circumferential strain rate. PDE5 phosphodiesterase 5