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Table 1 Comparison between paclitaxel, ifosfamide, carboplatin, and etoposide regimen and Einhorn regimen

From: Delayed rhabdomyolysis with paclitaxel, ifosfamide, carboplatin, and etoposide regimen: a case report

 

TI-CE regimen

Einhorn regimen

Conventional chemotherapy

TI = 2 cycles

Einhorn cytoreduction 1–2 cycles

Paclitaxel (T)

Ifosfamide (I)

Ifosfamide

Cisplatin

Vinblastine

Number of high-dose cycles with stem cell rescue

3

2

Etoposide dose

400 mg/m2 (D 1–3)

750 mg/m2 (D 1–3)

Carboplatin dose

AUC = 8 (D 1–3)

700 mg/m2 (D 1–3)

  1. Einhorn regimen uses carboplatin 700 mg/m2 body-surface area instead of AUC = 8 and etoposide 750 mg/m2, which is higher than the dose in TIGER regimen (etoposide 400 mg/m2). In TI-CE approach, carboplatin and etoposide high-dose therapy is given in three cycles every 21 days, whereas in Einhorn regimen, it is given in two cycles
  2. AUC area under the concentration-time curve, D days, TI paclitaxel and ifosfamide, TI-CE paclitaxel + ifosfamide and carboplatin + etoposide
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Journal of Medical Case Reports

ISSN: 1752-1947