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Table 2 Results of infectious disease workup

From: Secondary hemophagocytic lymphohistiocytosis in the setting of metastatic renal cell carcinoma: a case report

Source Test result
Blood Cultures: no growth (bacterial/fungal) Negative for HIV 1/2 and HIV p24 Ag Nonreactive for Lyme antibody and Treponema pallidum immunoassay Negative for Coccidioides IgM and IgG. Negative for Histoplasma Ag Viral hepatitis panel (A, B, C) significant only for hepatitis B core Ab EBV serology consistent with seropositive statusa CMV serology consistent with seronegative status
Urine Urinalysis significant only for trace proteinuria Negative for Legionella Ag Negative for Streptococcus pneumoniae Ag  
Nasopharyngeal swab Negative for Group A Streptococcus (direct antigen test) Negative for influenza A, B, RSV (rt-PCR) Negative for MSSA and MRSA     
Cerebrospinal fluid (CSF) CSF showed 14 nucleated cells/mm3 (normal 0–5/mm3) consisting of 84% polymorphonuclear leukocytes, 9% lymphocytes, and 7% monocytes; 44 mg/dL glucose (normal 41–70 mg/dL); 70 mg/dL protein (normal 15–45 mg/dL) Cryptococcus neoformans Ag and C. gattii Ag Nonreactive for West Nile virus IgG/IgM Negative for HSV 1, 2 and enterovirus (PCR) Negative for acid fast bacilli, no growth occurred during fungal and mycobacterial culture
Stool Negative for Clostridium difficile toxin B (PCR)       
Other PPD skin test 0-mm induration Quantiferon Gold tuberculosis test indeterminate      
  1. Ab antibody, Ag antigen, CMV cytomegalovirus, EBV Epstein-Barr virus, HSV herpes simplex virus, Ig immunoglobulin, MSSA methicillin-sensitive Staphylococcus aureus, MRSA methicillin-resistant Staphylococcus aureus, PCR polymerase chain reaction, PPD purified protein derivative, RSV respiratory syncytial virus
  2. aEBV viral capsid, nuclear, and early diffuse IgG Abs reactive, viral capsid IgM nonreactive; EBV PCR not performed