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Table 2 Results of infectious disease workup

From: Secondary hemophagocytic lymphohistiocytosis in the setting of metastatic renal cell carcinoma: a case report

Source

Test result

Blood

Cultures: no growth (bacterial/fungal)

Negative for HIV 1/2 and HIV p24 Ag

Nonreactive for Lyme antibody and Treponema pallidum immunoassay

Negative for Coccidioides IgM and IgG. Negative for Histoplasma Ag

Viral hepatitis panel (A, B, C) significant only for hepatitis B core Ab

EBV serology consistent with seropositive statusa

CMV serology consistent with seronegative status

Urine

Urinalysis significant only for trace proteinuria

Negative for Legionella Ag

Negative for Streptococcus pneumoniae Ag

 

Nasopharyngeal swab

Negative for Group A Streptococcus (direct antigen test)

Negative for influenza A, B, RSV (rt-PCR)

Negative for MSSA and MRSA

    

Cerebrospinal fluid (CSF)

CSF showed 14 nucleated cells/mm3 (normal 0–5/mm3) consisting of 84% polymorphonuclear leukocytes, 9% lymphocytes, and 7% monocytes; 44 mg/dL glucose (normal 41–70 mg/dL); 70 mg/dL protein (normal 15–45 mg/dL)

Cryptococcus neoformans Ag and C. gattii Ag

Nonreactive for West Nile virus IgG/IgM

Negative for HSV 1, 2 and enterovirus (PCR)

Negative for acid fast bacilli, no growth occurred during fungal and mycobacterial culture

Stool

Negative for Clostridium difficile toxin B (PCR)

      

Other

PPD skin test 0-mm induration

Quantiferon Gold tuberculosis test indeterminate

     
  1. Ab antibody, Ag antigen, CMV cytomegalovirus, EBV Epstein-Barr virus, HSV herpes simplex virus, Ig immunoglobulin, MSSA methicillin-sensitive Staphylococcus aureus, MRSA methicillin-resistant Staphylococcus aureus, PCR polymerase chain reaction, PPD purified protein derivative, RSV respiratory syncytial virus
  2. aEBV viral capsid, nuclear, and early diffuse IgG Abs reactive, viral capsid IgM nonreactive; EBV PCR not performed