Table 1 Characteristics of various published cases of skull base radiation-induced osteosarcoma

Amine (1976) [32]

16/F

Pituitary adenoma

51.0

10

Sella

Radiation

5 weeks

Tanaka (1989) [33]

57/M

Craniopharyngioma

110

15

Sphenoid wing

Embolization surgery

2 weeks

Salvati (1994) [34]

45/M

Pituitary adenoma

44

12

Sphenoid

Radiation (50 Gy)

16 months

Gnanalingham (2002) [35]

67/F

Pituitary adenoma

52

14

Sella

Surgery

–

Hansen (2003) [36]

39/M

Pituitary adenoma

52

22

Sella, clivus

Surgery

Short

Bembo (2004) [37]

45

Pituitary adenoma

46

5

Sella

Surgery

7 weeks

Patel (2011) [15]

44

Craniopharyngioma

60

9

Sphenoid-ethmoid sinus

Chemotherapy

16 months

Yamada (2012) [38]

75/F

Pituitary adenoma

50

20

Sphenoid sinus

Cyberknife surgery, chemotherapy

24 months

Patel (2011) [15]

54/M

Maxillary and adenoid cystic carcinoma

60

12

Sphenoid, frontal and temporal bone

Surgery, chemotherapy

13 months

63/M

Squamous cell carcinoma, nasal cavity

–

4.5

Palate + maxillary sinus

Surgery, chemotherapy

47 months

50/M

Squamous cell carcinoma, nasal cavity

–

14

Infratemporal fossa

Surgery, chemotherapy

17 years

44/F

Craniopharyngioma

–

9

Sphenoidal, ethmoidal bone

Chemotherapy

18 months

15/M

Retinoblastoma

–

15

Zygoma

Surgery, chemotherapy

62 months

22/M

Retinoblastoma

–

20

Ethmoid + maxillary sinus

Surgery, chemotherapy

–

10/M

Rhabdomyosarcoma

–

6.75

Mastoid + jugular foramen

Surgery, chemotherapy, radiation

29 months

31/M

Rhabdomyosarcoma

60

18

Palate + infratemporal fossa

Surgery, chemotherapy

143 months

26/M

Retinoblastoma

35

25

Surgery, chemotherapy

41 months

Hansen (2003) [36]

29/M

Pituitary adenoma

5000 rad

22

Sphenoid, frontal clivus

Chemotherapy

Very short

Patel (2014) [39]

52/M

Craniopharyngioma

50

22

Sella + clivus

Surgery

1 month

Our patient

28/M

Nasopharynx carcinoma

70

11

Sphenoid + maxillary bone

Chemotherapy

6 months