Fig. 1

Chronological changes in the brain and lung abscesses. a Image studies: top, chest computed tomography scan; middle, chest X-ray; and bottom, head magnetic resonance imaging with contrast medium. b Alterations in body temperature (black), C-reactive protein levels (blue), and β-D-glucan levels (green) in response to the changes in antibiotics and antifungals. Daily doses: clindamycin 600 mg, twice a day; imipenem/cilastatin sodium 0.5 g, twice a day; cefepime dihydrochloride hydrate 1 g, twice a day; cefotiam hydrochloride 1 g, twice a day; levofloxacin hydrate 500 mg, once a day; ceftazidime hydrate 1 g, twice a day; fosfluconazole 800 mg, once a day on the first day, and 400 mg, once a day after second day; micafungin sodium 150 mg, once a day; and caspofungin acetate 70 mg, once a day on the first day, and 50 mg, once a day after second day. The red horizontal line in the graph indicates the body temperature level of 37 °C and CRP level of 10 mg/dl. CAZ ceftazidime hydrate, CFPM cefepime dihydrochloride hydrate, CLDM clindamycin, CPFG caspofungin acetate, CRP C-reactive protein, CTM cefotiam hydrochloride, CTX cefotaxime, F-FLCZ fosfluconazole, IMP/CS imipenem/cilastatin sodium, LVFX levofloxacin hydrate, MCFG micafungin sodium