Prenatal sonographic diagnosis of fetal valproate syndrome: a case report

Table 1 Reported cases of fetal valproate syndrome detected by prenatal ultrasonography

Author	Maternal age	Antiepileptic drugs	US findings of fetus (gestational weeks)	Delivery	Additional postnatal findings
Witters et al. 2002 [7]	40 years	VPA; 1000 mg/day	Flat nasal bridge with short nose (21 weeks)	Term-delivery female	Long philtrum, thin upper lip, long toes
Kennelly and Moran 2007 [8]	N/A	VPA; dose N/A	Bilateral radial ray defects (19 weeks)	Termination of pregnancy	Aortic valve stenosis
Our case	27 years	VPA 1400 mg/day PB 140 mg/day CBZ 1200 mg/day	Contracture of right wrist joint suggestive of radial ray defect (25 weeks)	Term-delivery female	VSD, ASD, PDA; shallow philtrum; euryopia
Our case	27 years	VPA 1400 mg/day PB 140 mg/day CBZ 1200 mg/day	Saddle nose (37 weeks)	Term-delivery female	VSD, ASD, PDA; shallow philtrum; euryopia

Abbreviations: US Ultrasonography, VPA Valproate, PB Phenobarbital, CBZ Carbamazepine, VSD Ventricular septal defect, ASD Atrial septal defect, PDA Patent ductus arteriosus, N/A Not available

ISSN: 1752-1947