Fig. 3From: Next-generation sequencing and a novel COL3A1 mutation associated with vascular Ehlers–Danlos syndrome with severe intestinal involvement: a case reportData analysis. PolyPhen-2 prediction indicated that a c.1493G>A (p.G498D) probably damages the structure of the protein (on the basis of two different datasets Human Diversity and Human Variation). b Align GVGD indicated that c.1493G>A (p.G498D) is deleterious (class 65)Back to article page