Table 1 Timeline of the patient’s clinical course
From: Chordoma dedifferentiation after proton beam therapy: a case report and review of the literature
Date | Event |
|---|---|
16 Jun 2012 | Initial presentation with headaches and emesis prompts magnetic resonance imaging that shows a large heterogeneous skull base mass suspicious for chordoma. |
2 Jul 2012 | Endonasal surgical resection. Surgical pathology confirms chordoma diagnosis. |
2 Nov – 29 Nov 2012 | Fractionated proton and photon beam therapy: 77.4 Gy total, 59.4 Gy (cobalt gray equivalent) in 33 fractions with protons and 18 Gy in 10 fractions with photons. |
18 Jun – 11 Dec 2013 | Interval decrease in tumor size visualized at scheduled magnetic resonance imagings. |
3 Jan 2015 | Visual disturbances prompt magnetic resonance imaging, which shows an enhancing mass in the resection site suspicious for recurrence with dedifferentiation. |
21 Jan 2015 | Retrosigmoid craniotomy. Surgical pathology shows complete dedifferentiation. |
29 Mar 2015 | Begins ifosfamide and etoposide alternating every 2 weeks with vincristine, doxorubicin, and cyclophosphamide. |
23 Apr 2015 – 25 Mar 2016 | Interval decrease in tumor size visualized at scheduled magnetic resonance imagings. Continues ifosfamide and etoposide alternating every 2 weeks with vincristine, doxorubicin, and cyclophosphamide. |
26 Apr 2016 | Last of 17 cycles of ifosfamide and etoposide alternating with vincristine, doxorubicin, and cyclophosphamide. Begins maintenance capecitabine. |